地 址 :
台北市北投區(112)立農街二段155號

Address:
155, Li-Nong St. , Sec.2, Peitou, Taipei , Taiwan

電話 /Tel: 02-2826-7389
傳真 /Fax: 02-2827-3123

Email: ibs@ym.edu.tw
http://www.ym.edu.tw/ibs
 

周元華 助理教授 Assistant Prof. Yuan-Hwa Chou, MD, Ph.D
 

陽明大學 腦科學研究所 專任助理教授
陽明大學 醫學系 助理教授
台北榮民總醫院 精神部 醫師
Tel: (02) 2871-2121#2027-271
E-mail : c520608@ms64.hinet.net
 

教師專長

精神醫學, 腦影像學

 

研究概況

Dopamine transporters與receptors、憂鬱症相關的研究及PET（positron emission tomography，正子造影）技術的應用。

 

獲獎記錄

2002 世界神經精神藥理大會最佳海報獎（比利時．布魯塞爾）

 

發表論文

SCI publications

  1. Chou YH. Wei J. Lin CI (1991) Halothane inhibits residual fast sodium channels in human atrial muscle. Anesthesiology 75(4):716-7.
  2. Halldin C, Foged C, Chou YH, Karlsson P, Swahn CG, Sandell J, Sedvall G, Farde L (1998) Carbon-11-NNC 112: A radioligand for PET examination of striatal and neocortical D1 dopamine receptors. The Journal of Nuclear Medicine 39:2061-2068.
  3. Chou YH, Karlsson P, Halldin C, Olsson H, Farde L (1999) A PET study of D1-like dopamine receptor ligand binding during altered endogenous dopamine levels in the primate brain. Psychopharmacology 146(2):220-227.
  4. Gulyas B, Halldin C, Karlsson P, Chou YH, Swahn C-G, Bonock P, Paroczai M, Farde L (1999) Brain uptake and plasma metabolism of [11C]vinpocetine. A preliminary PET-study in cynomolgus monkey. Journal of Neuroimaging 9:217-222.
  5. Helfenbein J, Sandell J, Halldin C, Chalon S, Emond P, Okubo Y, Chou YH, Frangin Y, Douziech L, Gareau L, Swahn C-G, Besnard J-C, Farde L, Guilloteay D (1999) PET examination of three potent cocaine derivatives as specific radioligands for the serotonin transporter. Nuclear Medicine & Biology 26:491-499.
  6. Farde L, Ginovart N, Halldin C, Chou YH, Olsson H, Lundqvist C, Swahn C-G (2000) A PET study of [11C]beta-CIT-FE binding to the dopamine transporter in the monkey and human brain. International Journal of Neuropsychopharmacology 3:203-214.
  7. Sandell J, Halldin C, Helfenbein J, Chou YH, Emond P, Swahn C-G, Guilloteay D Farde L (2000) Synthesis of [11C]2- beta-carbomethoxy-3-beta-(3’-iodo-4’- methyl,-ethyl and isopropyl phenyl)nortropane as potential radiotracers for examination of the serotonin transporter with positron emission tomography. Journal of Labelled Compounds and Radiopharmaceuticals 43:1033-1046.
  8. Chou YH, Halldin C, Farde L (2000) Effect of amphetamine on extrastriatal D2 dopamine receptor binding in the primate brain: A PET study. Synapse 38:138-143.
  9. Langer O, Halldin C, Chou YH, Sandell J, Swahn C-G, Nagren K, Perrone R, Berardi F, Leopoldi M, Farde L (2000) Carbon-11 BD12, an attempt to visualise dopamine D4 receptors in the primate brain with positron emission tomography. Nuclear Medicine & Biology 27:707-714.
  10. Sandell J, Halldin C, Pike VW, Chou YH, Varnas K, Hall H, Marchais S, Nowicki B, Wikstrom H, Swahn C-G, Farde L (2001) New halogenated [11C]6FPWAY and [11C]6BPWAY – radiosynthesis and assessment as radioligands for the study of brain 5-HT1A receptors in living monkey. Nuclear Medicine & Biology 28(2):177-85.
  11. Sandell J, Halldin C, Chou YH, Swahn C-G, Thorberg SO, Werner T, Sohn D, Sedvall G, Farde L (2002) PET examination and metabolism in monkey of [11C]NAD-299, a radioligand for the 5-HT1A receptor. Nuclear Medicine & Biology 29(1):39-45.
  12. Sandell J, Halldin C, Sovago J, Chou YH, Gulyas B, Yu M, Emond P, Nagren K, Guilloteau D, Farde L (2002) PET examination of [(11)C]5-methyl-6-nitroquipazine, a radioligand for visualization of the serotonin transporter. Nuclear Medicine & Biology. 29(6):651-6.
  13. Nyberg S, Chou YH, Halldin C (2002) Saturation of striatal D2 dopamine receptors by clozapine. International Journal of Neuropsychopharmacology 5:11-16.
  14. Huang WS, Ma KH,Chou YH,Chen CY,Liu RS, Liu JC (2003) Tc-99m TRODAT –1 SPECT in healthy and 6-OHDA lesioned parkinsonian monkeys: comparison with F-18 FDOPA PET. Nuclear Medicine Communication 24:77-83.
  15. Chou YH, Halldin C, Farde L (2003) Occupancy of 5-HT1A receptors by clozapine in the monkey brain: A PET study. Psychopharmacology 166:234-240.
  16. Huang WS, Chiang YH, Lin JC, Chou YH, Cheng CY, Liu RS (2003) Cross over study of Tc-99m TRODAT-1 SPECT and F-18 FDOPA PET in Parkinson’s disease patients. The Journal of Nuclear Medicine 44(7): 999-1005.
  17. Halldin C, Erixon-Lindroth N, Pauli S, Chou YH, Okubo Y, Karlsson P, Lundkvist C, Olsson H, Guilloteau D, Patrick E, Farde L (2003) [11C]PE2I – a Highly Selective Radioligand for PET-Examination of the Dopamine Transporter in Monkey and Human Brain. European Journal of Nuclear. Medicine 30:1220-1230.
  18. Balle T, Halldin C, Andersen L, Alifrangis LH, Badolo L, Jensen KG, Chou YH, Andersen K, Perregaard J, Farde L (2004) New α1 adrenoceptor antagonists derived from the antipsychotic sertindole – carbon-11 labelling and PET examination of brain uptake in the cynomolgus monkey. Nuclear Medicine & Biology 31:327-336.
  19. Huang SY, Lin WW, Ko HC, Lee JF, Wang TJ, Chou YH, Yin SJ, Lu RB (2004) Possible Interaction of ADH and ALDH genes with dopamine D2 receptor (DRD2) gene in anxiety-depressive alcoholism. Alcoholism: Clinical and Experimental Research 28(3):374-84.
  20. Chen CK, Chou YH (2004) Amisulpride-associated pedal edema. European Psychiatry 19(7):454-5..
  21. Huang WS. Ma KH. Cheng CY. Chen CY. Fu YK. Chou YH. Wey SP. Liu JC (2004) Imaging serotonin transporters with 123I-ADAM brain SPECT in healthy non-human primates. Nuclear Medicine Communications. 25(5):515-9.
  22. Marchais-Oberwinkler S. Nowicki B. Pike VW. Halldin C. Sandell J. Chou YH. Gulyas B. Brennum LT. Farde L. Wikstrom HV. (2005) N-Oxide analogs of WAY-100635: new high affinity 5-HT(1A) receptor antagonists. Bioorganic & Medicinal Chemistry. 13(3):883-9.
  23. Gu SL, Su TP, Chou YH (2005) Ziprasidone induced pedal edema. (submission).
  24. Chou YH, Huang WS. Su TP, Fu YK (2005) Simultaneous measurement of dopamine transporters and D2/D3 receptors in drug naive schizophrenia. (submission).
  25. Wang TS, Chou YH, Shiah IS (2006) Combined Treatment of Olanzapine and Mirtazapine in Anorexia Nervosa Associated with Major Depression. Prog Neuropsychopharmacol Biol Psychiatry. 30(2):306-9
  26. Chou YH, Halldin C, Farde L (2006) Clozapine binds preferentially to cortical D1-like dopamine receptors in the primate brain: a PET study. Psychopharmacology, 185(1), 29-35.
  27. Ku HL, Su TP, Chou YH. (2006) Ziprasidone-associated pedal edema in the treatment of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 30(5):963-4.
  28. Chou YH, Huang WS, Su TP, Wan FJ, Lu RB, Fu YK, Wey SP (2006) Dopamine transporters and cognitive function in methamphetamine abuser after a short abstinence: A SPECT study. Eur Neuropsychopharmacol. Jul 12 [Epub ahead of print]

Non-SCI publications

  1. Chou YH (1990) Cellular mechanisms responsible for the depressant effects of halothane in human atrial and dog Purkinje fibers: Role of sodium ion. Master thesis, National Defense Medical Center, Taipei, Taiwan, R.O.C.
  2. Chou YH (1992) Amphetamine delusional disorder. Medical Digest 15:545-547.
  3. Chou YH (2001) A PET study on dopamine and serotonin receptor binding in the primate brain. Ph.D. thesis, Karolinska Institutet, Stockholm, Sweden.
  4. Gulyas Balazs dr., Halldin Christer dr., Karlsson Per dr., Chou Yuan-Hwa dr., Swahn Carl-Gunnar dr., Bonoczk Peter dr., es Farde Lars dr. (1999) [11C]Vinpocetine agyi felvetele es metabolizmusa majomban: PET vizsgalatok. Orvosi Hetilap 140(30):1687-1691.
  5. Huang WS, Ma KH, Chou YH, Chen CH, Chen CY, Wey SP, Ting G, Liu JC (2002) 123I-ADAM SPECT in healthy nonhuman primates: A preliminary report. Annals of Nuclear Medicine Science 15: 27-32.
  6. Wang TS, Chou YH (2005) Sertraline elevates plasma prolactin levels in a case of male to female transsexualism. Journal of Medical Sciences 25(1): 45-47.
  7. Chou YH, Su TP (2005) Recent advances in antipsychotics. Clinical Medicine 55(4): 247-252.
  8. Huang GK, Chou YH (2005) Schizophrenia Clinical Medicine 55(6) 415-425.
  9. Chou YH, Wang SJ, Yang BH, Su TP (2006) Receptor image in psychiatry. Taiwanese Journal of Psychiatry. (in press).